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KMID : 0380919960250010046
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Journal of the Korean Society of Food Nutrition
1996 Volume.25 No. 1 p.46 ~ p.52
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Effect of Water Extract from Fugu xanthopterus on the Hyperuricemia in Alcohol - treated Rats
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Kim Seok-Hwan
Lee Kyoung-Hee
Shin Du-Lim
Kim Dong-Hoon
Choi Jong-Won
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Abstract
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The present study was undertaken to investigate the effect of the water extract of the puffer fish Fugu xanthopterus(FXH) on the alcohol induced hyperuricemia. The normal group and the FXH treated group showed no significant changes in the levels of blood uric acid but, the blood uric acid significantly decreased in the FXH treated rats with 100㎎ / ㎏ for two weeks compared to the ethanol treated group. There were no significant changes in the activities of uricase, adenosine deaminase, guanine deaminase, and purine nucleoside phosphorylase, among all the test group. But the activitis of liver xanthine oxidase were recovered to the normal level in ethanol+FXH treated group comparing to the ethanol treated group. Furthermore, ethanol+FXH treated rats showed the similar pattern in the levels of blood uric acid and urinary allantoin with normal group. These results indicate that the decreased blood uric acid by the FXH treatment of the alcohol induced hyperuricemia rats may result from decreased activity of hepatic xanthine oxidase.
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KEYWORD
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puffer fish Fugu xanthopterus, subaxute alcohol intoxication, purine metabolism, xanthine oxidas
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